Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
Identifieur interne : 000932 ( Main/Exploration ); précédent : 000931; suivant : 000933Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
Auteurs : Marion Maurel ; Joanna Obacz ; Tony Avril ; Yong-Ping Ding ; Olga Papadodima ; Xavier Treton ; Fanny Daniel ; Eleftherios Pilalis ; Johanna Hörberg ; Wenyang Hou ; Marie-Claude Beauchamp ; Julien Tourneur-Marsille ; Dominique Cazals-Hatem ; Lucia Sommerova ; Afshin Samali ; Jan Tavernier ; Roman Hrstka ; Aurélien Dupont ; Delphine Fessart ; Frédéric Delom ; Martin E. Fernandez-Zapico ; Gregor Jansen ; Leif A. Eriksson ; David Y. Thomas ; Loydie Jerome-Majewska ; Ted Hupp ; Aristotelis Chatziioannou ; Eric Chevet ; Eric Ogier-DenisSource :
- EMBO Molecular Medicine [ 1757-4676 ] ; 2019.
Abstract
Anterior gradient 2 (
Url:
DOI: 10.15252/emmm.201810120
PubMed: 31040128
PubMed Central: 6554669
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Control of anterior <styled-content style="fixed-case">GR</styled-content>adient 2 (<styled-content style="fixed-case">AGR</styled-content>2) dimerization links endoplasmic reticulum proteostasis to inflammation</title><author><name sortKey="Maurel, Marion" sort="Maurel, Marion" uniqKey="Maurel M" first="Marion" last="Maurel">Marion Maurel</name><affiliation><nlm:aff id="emmm201810120-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Obacz, Joanna" sort="Obacz, Joanna" uniqKey="Obacz J" first="Joanna" last="Obacz">Joanna Obacz</name><affiliation><nlm:aff id="emmm201810120-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Avril, Tony" sort="Avril, Tony" uniqKey="Avril T" first="Tony" last="Avril">Tony Avril</name><affiliation><nlm:aff id="emmm201810120-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Ding, Yong Ing" sort="Ding, Yong Ing" uniqKey="Ding Y" first="Yong-Ping" last="Ding">Yong-Ping Ding</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Papadodima, Olga" sort="Papadodima, Olga" uniqKey="Papadodima O" first="Olga" last="Papadodima">Olga Papadodima</name><affiliation><nlm:aff id="emmm201810120-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Treton, Xavier" sort="Treton, Xavier" uniqKey="Treton X" first="Xavier" last="Treton">Xavier Treton</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Daniel, Fanny" sort="Daniel, Fanny" uniqKey="Daniel F" first="Fanny" last="Daniel">Fanny Daniel</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Pilalis, Eleftherios" sort="Pilalis, Eleftherios" uniqKey="Pilalis E" first="Eleftherios" last="Pilalis">Eleftherios Pilalis</name><affiliation><nlm:aff id="emmm201810120-aff-0008"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Horberg, Johanna" sort="Horberg, Johanna" uniqKey="Horberg J" first="Johanna" last="Hörberg">Johanna Hörberg</name><affiliation><nlm:aff id="emmm201810120-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Hou, Wenyang" sort="Hou, Wenyang" uniqKey="Hou W" first="Wenyang" last="Hou">Wenyang Hou</name><affiliation><nlm:aff id="emmm201810120-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Beauchamp, Marie Laude" sort="Beauchamp, Marie Laude" uniqKey="Beauchamp M" first="Marie-Claude" last="Beauchamp">Marie-Claude Beauchamp</name><affiliation><nlm:aff id="emmm201810120-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Tourneur Arsille, Julien" sort="Tourneur Arsille, Julien" uniqKey="Tourneur Arsille J" first="Julien" last="Tourneur-Marsille">Julien Tourneur-Marsille</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Cazals Atem, Dominique" sort="Cazals Atem, Dominique" uniqKey="Cazals Atem D" first="Dominique" last="Cazals-Hatem">Dominique Cazals-Hatem</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Sommerova, Lucia" sort="Sommerova, Lucia" uniqKey="Sommerova L" first="Lucia" last="Sommerova">Lucia Sommerova</name><affiliation><nlm:aff id="emmm201810120-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Samali, Afshin" sort="Samali, Afshin" uniqKey="Samali A" first="Afshin" last="Samali">Afshin Samali</name><affiliation><nlm:aff id="emmm201810120-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Tavernier, Jan" sort="Tavernier, Jan" uniqKey="Tavernier J" first="Jan" last="Tavernier">Jan Tavernier</name><affiliation><nlm:aff id="emmm201810120-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Hrstka, Roman" sort="Hrstka, Roman" uniqKey="Hrstka R" first="Roman" last="Hrstka">Roman Hrstka</name><affiliation><nlm:aff id="emmm201810120-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Dupont, Aurelien" sort="Dupont, Aurelien" uniqKey="Dupont A" first="Aurélien" last="Dupont">Aurélien Dupont</name><affiliation><nlm:aff id="emmm201810120-aff-0013"></nlm:aff></affiliation></author><author><name sortKey="Fessart, Delphine" sort="Fessart, Delphine" uniqKey="Fessart D" first="Delphine" last="Fessart">Delphine Fessart</name><affiliation><nlm:aff id="emmm201810120-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Delom, Frederic" sort="Delom, Frederic" uniqKey="Delom F" first="Frédéric" last="Delom">Frédéric Delom</name><affiliation><nlm:aff id="emmm201810120-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Fernandez Apico, Martin E" sort="Fernandez Apico, Martin E" uniqKey="Fernandez Apico M" first="Martin E" last="Fernandez-Zapico">Martin E. Fernandez-Zapico</name><affiliation><nlm:aff id="emmm201810120-aff-0015"></nlm:aff></affiliation></author><author><name sortKey="Jansen, Gregor" sort="Jansen, Gregor" uniqKey="Jansen G" first="Gregor" last="Jansen">Gregor Jansen</name><affiliation><nlm:aff id="emmm201810120-aff-0016"></nlm:aff></affiliation></author><author><name sortKey="Eriksson, Leif A" sort="Eriksson, Leif A" uniqKey="Eriksson L" first="Leif A" last="Eriksson">Leif A. Eriksson</name><affiliation><nlm:aff id="emmm201810120-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Thomas, David Y" sort="Thomas, David Y" uniqKey="Thomas D" first="David Y" last="Thomas">David Y. Thomas</name><affiliation><nlm:aff id="emmm201810120-aff-0016"></nlm:aff></affiliation></author><author><name sortKey="Jerome Ajewska, Loydie" sort="Jerome Ajewska, Loydie" uniqKey="Jerome Ajewska L" first="Loydie" last="Jerome-Majewska">Loydie Jerome-Majewska</name><affiliation><nlm:aff id="emmm201810120-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Hupp, Ted" sort="Hupp, Ted" uniqKey="Hupp T" first="Ted" last="Hupp">Ted Hupp</name><affiliation><nlm:aff id="emmm201810120-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0012"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0017"></nlm:aff></affiliation></author><author><name sortKey="Chatziioannou, Aristotelis" sort="Chatziioannou, Aristotelis" uniqKey="Chatziioannou A" first="Aristotelis" last="Chatziioannou">Aristotelis Chatziioannou</name><affiliation><nlm:aff id="emmm201810120-aff-0008"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0018"></nlm:aff></affiliation></author><author><name sortKey="Chevet, Eric" sort="Chevet, Eric" uniqKey="Chevet E" first="Eric" last="Chevet">Eric Chevet</name><affiliation><nlm:aff id="emmm201810120-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Ogier Enis, Eric" sort="Ogier Enis, Eric" uniqKey="Ogier Enis E" first="Eric" last="Ogier-Denis">Eric Ogier-Denis</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31040128</idno><idno type="pmc">6554669</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554669</idno><idno type="RBID">PMC:6554669</idno><idno type="doi">10.15252/emmm.201810120</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000507</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000507</idno><idno type="wicri:Area/Pmc/Curation">000507</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000507</idno><idno type="wicri:Area/Pmc/Checkpoint">000870</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000870</idno><idno type="wicri:Area/Ncbi/Merge">000575</idno><idno type="wicri:Area/Ncbi/Curation">000575</idno><idno type="wicri:Area/Ncbi/Checkpoint">000575</idno><idno type="wicri:doubleKey">1757-4676:2019:Maurel M:control:of:anterior</idno><idno type="wicri:Area/Main/Merge">000932</idno><idno type="wicri:Area/Main/Curation">000932</idno><idno type="wicri:Area/Main/Exploration">000932</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Control of anterior <styled-content style="fixed-case">GR</styled-content>adient 2 (<styled-content style="fixed-case">AGR</styled-content>2) dimerization links endoplasmic reticulum proteostasis to inflammation</title><author><name sortKey="Maurel, Marion" sort="Maurel, Marion" uniqKey="Maurel M" first="Marion" last="Maurel">Marion Maurel</name><affiliation><nlm:aff id="emmm201810120-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0002"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0003"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Obacz, Joanna" sort="Obacz, Joanna" uniqKey="Obacz J" first="Joanna" last="Obacz">Joanna Obacz</name><affiliation><nlm:aff id="emmm201810120-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Avril, Tony" sort="Avril, Tony" uniqKey="Avril T" first="Tony" last="Avril">Tony Avril</name><affiliation><nlm:aff id="emmm201810120-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Ding, Yong Ing" sort="Ding, Yong Ing" uniqKey="Ding Y" first="Yong-Ping" last="Ding">Yong-Ping Ding</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Papadodima, Olga" sort="Papadodima, Olga" uniqKey="Papadodima O" first="Olga" last="Papadodima">Olga Papadodima</name><affiliation><nlm:aff id="emmm201810120-aff-0008"></nlm:aff></affiliation></author><author><name sortKey="Treton, Xavier" sort="Treton, Xavier" uniqKey="Treton X" first="Xavier" last="Treton">Xavier Treton</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Daniel, Fanny" sort="Daniel, Fanny" uniqKey="Daniel F" first="Fanny" last="Daniel">Fanny Daniel</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Pilalis, Eleftherios" sort="Pilalis, Eleftherios" uniqKey="Pilalis E" first="Eleftherios" last="Pilalis">Eleftherios Pilalis</name><affiliation><nlm:aff id="emmm201810120-aff-0008"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0009"></nlm:aff></affiliation></author><author><name sortKey="Horberg, Johanna" sort="Horberg, Johanna" uniqKey="Horberg J" first="Johanna" last="Hörberg">Johanna Hörberg</name><affiliation><nlm:aff id="emmm201810120-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Hou, Wenyang" sort="Hou, Wenyang" uniqKey="Hou W" first="Wenyang" last="Hou">Wenyang Hou</name><affiliation><nlm:aff id="emmm201810120-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Beauchamp, Marie Laude" sort="Beauchamp, Marie Laude" uniqKey="Beauchamp M" first="Marie-Claude" last="Beauchamp">Marie-Claude Beauchamp</name><affiliation><nlm:aff id="emmm201810120-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Tourneur Arsille, Julien" sort="Tourneur Arsille, Julien" uniqKey="Tourneur Arsille J" first="Julien" last="Tourneur-Marsille">Julien Tourneur-Marsille</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Cazals Atem, Dominique" sort="Cazals Atem, Dominique" uniqKey="Cazals Atem D" first="Dominique" last="Cazals-Hatem">Dominique Cazals-Hatem</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author><author><name sortKey="Sommerova, Lucia" sort="Sommerova, Lucia" uniqKey="Sommerova L" first="Lucia" last="Sommerova">Lucia Sommerova</name><affiliation><nlm:aff id="emmm201810120-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Samali, Afshin" sort="Samali, Afshin" uniqKey="Samali A" first="Afshin" last="Samali">Afshin Samali</name><affiliation><nlm:aff id="emmm201810120-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Tavernier, Jan" sort="Tavernier, Jan" uniqKey="Tavernier J" first="Jan" last="Tavernier">Jan Tavernier</name><affiliation><nlm:aff id="emmm201810120-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Hrstka, Roman" sort="Hrstka, Roman" uniqKey="Hrstka R" first="Roman" last="Hrstka">Roman Hrstka</name><affiliation><nlm:aff id="emmm201810120-aff-0012"></nlm:aff></affiliation></author><author><name sortKey="Dupont, Aurelien" sort="Dupont, Aurelien" uniqKey="Dupont A" first="Aurélien" last="Dupont">Aurélien Dupont</name><affiliation><nlm:aff id="emmm201810120-aff-0013"></nlm:aff></affiliation></author><author><name sortKey="Fessart, Delphine" sort="Fessart, Delphine" uniqKey="Fessart D" first="Delphine" last="Fessart">Delphine Fessart</name><affiliation><nlm:aff id="emmm201810120-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Delom, Frederic" sort="Delom, Frederic" uniqKey="Delom F" first="Frédéric" last="Delom">Frédéric Delom</name><affiliation><nlm:aff id="emmm201810120-aff-0014"></nlm:aff></affiliation></author><author><name sortKey="Fernandez Apico, Martin E" sort="Fernandez Apico, Martin E" uniqKey="Fernandez Apico M" first="Martin E" last="Fernandez-Zapico">Martin E. Fernandez-Zapico</name><affiliation><nlm:aff id="emmm201810120-aff-0015"></nlm:aff></affiliation></author><author><name sortKey="Jansen, Gregor" sort="Jansen, Gregor" uniqKey="Jansen G" first="Gregor" last="Jansen">Gregor Jansen</name><affiliation><nlm:aff id="emmm201810120-aff-0016"></nlm:aff></affiliation></author><author><name sortKey="Eriksson, Leif A" sort="Eriksson, Leif A" uniqKey="Eriksson L" first="Leif A" last="Eriksson">Leif A. Eriksson</name><affiliation><nlm:aff id="emmm201810120-aff-0010"></nlm:aff></affiliation></author><author><name sortKey="Thomas, David Y" sort="Thomas, David Y" uniqKey="Thomas D" first="David Y" last="Thomas">David Y. Thomas</name><affiliation><nlm:aff id="emmm201810120-aff-0016"></nlm:aff></affiliation></author><author><name sortKey="Jerome Ajewska, Loydie" sort="Jerome Ajewska, Loydie" uniqKey="Jerome Ajewska L" first="Loydie" last="Jerome-Majewska">Loydie Jerome-Majewska</name><affiliation><nlm:aff id="emmm201810120-aff-0011"></nlm:aff></affiliation></author><author><name sortKey="Hupp, Ted" sort="Hupp, Ted" uniqKey="Hupp T" first="Ted" last="Hupp">Ted Hupp</name><affiliation><nlm:aff id="emmm201810120-aff-0009"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0012"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0017"></nlm:aff></affiliation></author><author><name sortKey="Chatziioannou, Aristotelis" sort="Chatziioannou, Aristotelis" uniqKey="Chatziioannou A" first="Aristotelis" last="Chatziioannou">Aristotelis Chatziioannou</name><affiliation><nlm:aff id="emmm201810120-aff-0008"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0018"></nlm:aff></affiliation></author><author><name sortKey="Chevet, Eric" sort="Chevet, Eric" uniqKey="Chevet E" first="Eric" last="Chevet">Eric Chevet</name><affiliation><nlm:aff id="emmm201810120-aff-0001"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Ogier Enis, Eric" sort="Ogier Enis, Eric" uniqKey="Ogier Enis E" first="Eric" last="Ogier-Denis">Eric Ogier-Denis</name><affiliation><nlm:aff id="emmm201810120-aff-0005"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0006"></nlm:aff></affiliation><affiliation><nlm:aff id="emmm201810120-aff-0007"></nlm:aff></affiliation></author></analytic><series><title level="j">EMBO Molecular Medicine</title><idno type="ISSN">1757-4676</idno><idno type="eISSN">1757-4684</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Anterior gradient 2 (<styled-content style="fixed-case">AGR</styled-content>2) is a dimeric protein disulfide isomerase family member involved in the regulation of protein quality control in the endoplasmic reticulum (<styled-content style="fixed-case">ER</styled-content>). Mouse <styled-content style="fixed-case">AGR</styled-content>2 deletion increases intestinal inflammation and promotes the development of inflammatory bowel disease (<styled-content style="fixed-case">IBD</styled-content>). Although these biological effects are well established, the underlying molecular mechanisms of <styled-content style="fixed-case">AGR</styled-content>2 function toward inflammation remain poorly defined. Here, using a protein–protein interaction screen to identify cellular regulators of <styled-content style="fixed-case">AGR</styled-content>2 dimerization, we unveiled specific enhancers, including <styled-content style="fixed-case">TMED</styled-content>2, and inhibitors of <styled-content style="fixed-case">AGR</styled-content>2 dimerization, that control <styled-content style="fixed-case">AGR</styled-content>2 functions. We demonstrate that modulation of <styled-content style="fixed-case">AGR</styled-content>2 dimer formation, whether enhancing or inhibiting the process, yields pro‐inflammatory phenotypes, through either autophagy‐dependent processes or secretion of <styled-content style="fixed-case">AGR</styled-content>2, respectively. We also demonstrate that in <styled-content style="fixed-case">IBD</styled-content> and specifically in Crohn's disease, the levels of <styled-content style="fixed-case">AGR</styled-content>2 dimerization modulators are selectively deregulated, and this correlates with severity of disease. Our study demonstrates that <styled-content style="fixed-case">AGR</styled-content>2 dimers act as sensors of <styled-content style="fixed-case">ER</styled-content> homeostasis which are disrupted upon <styled-content style="fixed-case">ER</styled-content> stress and promote the secretion of <styled-content style="fixed-case">AGR</styled-content>2 monomers. The latter might represent systemic alarm signals for pro‐inflammatory responses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Avril, Tony" sort="Avril, Tony" uniqKey="Avril T" first="Tony" last="Avril">Tony Avril</name><name sortKey="Beauchamp, Marie Laude" sort="Beauchamp, Marie Laude" uniqKey="Beauchamp M" first="Marie-Claude" last="Beauchamp">Marie-Claude Beauchamp</name><name sortKey="Cazals Atem, Dominique" sort="Cazals Atem, Dominique" uniqKey="Cazals Atem D" first="Dominique" last="Cazals-Hatem">Dominique Cazals-Hatem</name><name sortKey="Chatziioannou, Aristotelis" sort="Chatziioannou, Aristotelis" uniqKey="Chatziioannou A" first="Aristotelis" last="Chatziioannou">Aristotelis Chatziioannou</name><name sortKey="Chevet, Eric" sort="Chevet, Eric" uniqKey="Chevet E" first="Eric" last="Chevet">Eric Chevet</name><name sortKey="Daniel, Fanny" sort="Daniel, Fanny" uniqKey="Daniel F" first="Fanny" last="Daniel">Fanny Daniel</name><name sortKey="Delom, Frederic" sort="Delom, Frederic" uniqKey="Delom F" first="Frédéric" last="Delom">Frédéric Delom</name><name sortKey="Ding, Yong Ing" sort="Ding, Yong Ing" uniqKey="Ding Y" first="Yong-Ping" last="Ding">Yong-Ping Ding</name><name sortKey="Dupont, Aurelien" sort="Dupont, Aurelien" uniqKey="Dupont A" first="Aurélien" last="Dupont">Aurélien Dupont</name><name sortKey="Eriksson, Leif A" sort="Eriksson, Leif A" uniqKey="Eriksson L" first="Leif A" last="Eriksson">Leif A. Eriksson</name><name sortKey="Fernandez Apico, Martin E" sort="Fernandez Apico, Martin E" uniqKey="Fernandez Apico M" first="Martin E" last="Fernandez-Zapico">Martin E. Fernandez-Zapico</name><name sortKey="Fessart, Delphine" sort="Fessart, Delphine" uniqKey="Fessart D" first="Delphine" last="Fessart">Delphine Fessart</name><name sortKey="Horberg, Johanna" sort="Horberg, Johanna" uniqKey="Horberg J" first="Johanna" last="Hörberg">Johanna Hörberg</name><name sortKey="Hou, Wenyang" sort="Hou, Wenyang" uniqKey="Hou W" first="Wenyang" last="Hou">Wenyang Hou</name><name sortKey="Hrstka, Roman" sort="Hrstka, Roman" uniqKey="Hrstka R" first="Roman" last="Hrstka">Roman Hrstka</name><name sortKey="Hupp, Ted" sort="Hupp, Ted" uniqKey="Hupp T" first="Ted" last="Hupp">Ted Hupp</name><name sortKey="Jansen, Gregor" sort="Jansen, Gregor" uniqKey="Jansen G" first="Gregor" last="Jansen">Gregor Jansen</name><name sortKey="Jerome Ajewska, Loydie" sort="Jerome Ajewska, Loydie" uniqKey="Jerome Ajewska L" first="Loydie" last="Jerome-Majewska">Loydie Jerome-Majewska</name><name sortKey="Maurel, Marion" sort="Maurel, Marion" uniqKey="Maurel M" first="Marion" last="Maurel">Marion Maurel</name><name sortKey="Obacz, Joanna" sort="Obacz, Joanna" uniqKey="Obacz J" first="Joanna" last="Obacz">Joanna Obacz</name><name sortKey="Ogier Enis, Eric" sort="Ogier Enis, Eric" uniqKey="Ogier Enis E" first="Eric" last="Ogier-Denis">Eric Ogier-Denis</name><name sortKey="Papadodima, Olga" sort="Papadodima, Olga" uniqKey="Papadodima O" first="Olga" last="Papadodima">Olga Papadodima</name><name sortKey="Pilalis, Eleftherios" sort="Pilalis, Eleftherios" uniqKey="Pilalis E" first="Eleftherios" last="Pilalis">Eleftherios Pilalis</name><name sortKey="Samali, Afshin" sort="Samali, Afshin" uniqKey="Samali A" first="Afshin" last="Samali">Afshin Samali</name><name sortKey="Sommerova, Lucia" sort="Sommerova, Lucia" uniqKey="Sommerova L" first="Lucia" last="Sommerova">Lucia Sommerova</name><name sortKey="Tavernier, Jan" sort="Tavernier, Jan" uniqKey="Tavernier J" first="Jan" last="Tavernier">Jan Tavernier</name><name sortKey="Thomas, David Y" sort="Thomas, David Y" uniqKey="Thomas D" first="David Y" last="Thomas">David Y. Thomas</name><name sortKey="Tourneur Arsille, Julien" sort="Tourneur Arsille, Julien" uniqKey="Tourneur Arsille J" first="Julien" last="Tourneur-Marsille">Julien Tourneur-Marsille</name><name sortKey="Treton, Xavier" sort="Treton, Xavier" uniqKey="Treton X" first="Xavier" last="Treton">Xavier Treton</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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